Two things off the top of my head... I'm running higher pressure injectors, but I built for a possible future with forced air induction. My injectors are way down on their duty cycle with the hope that they will last. I am running 61lb of fuel pressure at my regulator. In other words, over built, underutilized. As you know, LS motors like fuel pressure. Not sure if that's a good or bad idea though, but it seems to work well so far.
I also fought with the idea of blanking off the heater lines from/ to the water pump but ended up running hoses to my expansion tank. Boat runs cool and I have never had any air pockets or coolant troubles.
I also converted my boat from a carbed 383 that gave up its ghost to holley terminator x efi system. I'm new to the efi game but from what I've seen first hand after about 14 months of riding Kissimmee, Okeechobee, and the glades loaded to the gills with either bodies, hunting gear, or both, I'm a believer. I don't recall your route, but I cut my fuel tank and installed in tank dual fuel pumps that have been flawless. Actually, aside from slightly playing with pitch, and one oil pressure sensor going out, it has been flawless. Quick note on the oil pressure sensor: I recently installed a mech guage next to it on the oil filter manifold so that there is no more wondering if the sending unit is bad or if I really have erratic oil pressure. Just a peace of mind addition for verification.
The truth is, I'm not sure if any of my approach is correct. I've read a ton and there's no general consensus on any of it and I'm not a engine builder. I am, however familiar enough with motors and other systems having spent 36 years working in the maritime industry. Given your technical knowledge and detail oriented posts, I'm listening to what you're saying and very interested in your approach.
I'm running a 2.55 box with 3 jr blades about 24-25 degrees. Turning about 5300 or so rpm on a 13.6 D Back hull with stainless rigging. She will haul 5 of us with coolers and a grill up the hill without too much effort for lunch so I'm happy. Cruise is about 25 to 30 @ 2700 to 3300 rpm. On its maiden voyage my son and I hit 51 at 5k and it was climbing pretty good. I've thought about pulling some pitch out and spinning it up but don't need it. I just feel like I built it to be all in about 6k but again, I prefer being over built and underutilized rather than running on the ragged edge and maxing out everything .
Needless to say, I think I left myself some room to grow. Don't think I'll do it though. There's a lot of truth in these pages about costs being outrageous even if you're building it yourself.
I'm curious about your thoughts concerning the heater lines on these motors. Also, any comparative knowledge you or anyone else may have between a truck intake manifold and a fabricated aluminum intake from holley? I have the holley fab alum on my boat. I'm running a 102mm throttle body.